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RESEARCH PRODUCT

Late Breaking Abstract - Validation of a tool for the assessment of disease awareness (DA) in COPD

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Background: DA could influence adherence to treatment and outcomes. No validated tools are available to assess DA in COPD Aims: To generate a tool able to explore DA in COPD patients, the Disease Awareness in COPD Questionnaire (DACQ) Methods: A 2-step Delphi approach was used to develop a questionnaire that was tested for validity in a cohort of COPD patients of an Italian observational, multicenter, prospective study (SAT study - NCT02689492) Results: Consensus on a 27-item provisional questionnaire was obtained with 2 Delphi rounds. Factor analysis showed a 4-factor solution accounting for 35% of variance; each factor (disease acceptance, awareness of treatment needs, disease knowledge, disease perception) was adequate to partial credit Rasch model. In total, 7 items were removed leading to a final version with 20 items. The psychometric validation of the generated questionnaire was performed on 339 COPD patients with a 6.6 (6.9) diseae duration, CAT score 15.4 (7.7); FEV1 62.2% (21.2) predicted. The final questionnaire’s reliability was good (overall Cronbach’s α=0.72). Spearman correlation coefficient was -0.399, -0.288, 0.400 and -0.186 with Brief-Illness Perception Questionnaire, CAT, Treatment Satisfaction Questionnaire for Medication global satisfaction, and mMRC dyspnoea scale, respectively (p Conclusions: The DACQ showed good psychometric properties and highlighted a suboptimal level of DA in COPD patients