6533b86efe1ef96bd12cb309

RESEARCH PRODUCT

Investigations on the genetics and population genetics of the ?2 polymorphism

subject

description

The results of studies on 49 families with 107 children and various populations of Caucasoid, Negroid and Mongoloid origin concerning the genetics and population genetics of the β2-glycoprotein I polymorphism are reported. In general the genetical model proposed by Cleve (1968) is confirmed: two autosomal alleles BgN and BgD controlling the phenotypes Bg N-N, Bg N-D and Bg D-D. However, divergences from this model were found in two families. They indicate the assumption of non-genetic factors influencing the phenotype expression rather than more complicated genetical control mechanisms. Within Caucasoid populations phenotype and gene frequencies show almost a homogeneous distribution. This racial stock is striking due to a significant higher β2-glycoprotein I concentration in serum as compared to Negroids and Mongoloids. In connection with this, these racial stocks differ obviously in the gene frequencies: Caucasoids BgN=0.937, Negroids=0.742, Mongoloids =0.780; resp. BgD=0.063, 0.258, 0.220.