Prevalence and pattern of cognitive impairment in systemic lupus erythematosus patients with and without overt neuropsychiatric manifestations

6533b86efe1ef96bd12cb478

RESEARCH PRODUCT

Prevalence and pattern of cognitive impairment in systemic lupus erythematosus patients with and without overt neuropsychiatric manifestations

Alessandro Padovani Genesio Balestrieri Paola Bettini Elisabetta Del Zotto Luigi A. Vignolo Rosolino Camarda Roberto Cattaneo Elisabetta Cottini Roberto Monastero Angela Tincani

subject

Adult medicine.medical_specialty Anxiety Neuropsychological Tests Mental Processes Adrenal Cortex Hormones Memory Internal medicine medicine Humans Lupus Erythematosus Systemic Speech Systemic lupus erythematosus Neuropsychiatric SLE Cognitive impairment Neuropsychology Depression Attention Psychological testing Effects of sleep deprivation on cognitive performance Depression (differential diagnoses)Psychiatric Status Rating Scales Lupus erythematosus Depression Cognitive disorder Neuropsychology medicine.disease Connective tissue disease Memory Short-Term Neurology Mental Recall Physical therapy Female Settore MED/26 - Neurologia Neurology (clinical)Cognition Disorders Psychology Psychomotor Performance Psychopathology

description

The prevalence and pattern of cognitive impairment in systemic lupus erythematosus (SLE) patients with (NPSLE) and without (nSLE) overt neuropsychiatric manifestations were investigated. Fifty-two nSLE patients, 23 NPSLE patients and 27 healthy controls were evaluated with a battery of standardized neuropsychological and psychological tests. Disease duration, disease activity index, and current corticosteroid therapy were collected. Cognitive impairment was identified in 14 (26.9%) and in 12 (52.2%) of subjects with nSLE and NPSLE, respectively. Both SLE groups showed a significant impairment compared with controls on tasks assessing verbal and non-verbal long-term memory, and visuoconstructional abilities. In addition, NPSLE patients reported worse performances than both nSLE patients and controls on task evaluating short-term visuospatial memory. NPSLE subjects were significantly more anxious and depressed compared to both nSLE subjects and controls. By multivariate analysis, only depression levels, among clinical variables, significantly predicted cognitive performance. This study shows that cognitive impairment occurs frequently in both nSLE and NPSLE subjects. The higher frequency in NPSLE may be related to coexisting depressive disturbances.

year	journal	country	edition	language
2001-01-01	Journal of the Neurological Sciences

https://doi.org/10.1016/s0022-510x(00)00492-5