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RESEARCH PRODUCT
Emerging insights on the biological impact of extracellular vesicle-associated ncRNAs in multiple Myeloma
Nicola AmodioRaimondo StefaniaRiccardo AlessandroRiccardo AlessandroAlice ConigliaroOrnella UrzìLavinia Raimondisubject
0301 basic medicineBone diseaselcsh:QH426-470AngiogenesisReviewBiologyBiochemistry03 medical and health sciences0302 clinical medicineMultiple myelomaGeneticsmedicineNon-coding RNAMolecular BiologyMultiple myelomaRNAbiomarkersBiological activityExtracellular vesicleBiomarkermedicine.diseaseNon-coding RNAlcsh:Genetics030104 developmental biologymedicine.anatomical_structure030220 oncology & carcinogenesisDrug resistanceCancer researchBone marrowprogressionExtracellular vesicleextracellular vesiclesdescription
Increasing evidence indicates that extracellular vesicles (EVs) released from both tumor cells and the cells of the bone marrow microenvironment contribute to the pathobiology of multiple myeloma (MM). Recent studies on the mechanisms by which EVs exert their biological activity have indicated that the non-coding RNA (ncRNA) cargo is key in mediating their effect on MM development and progression. In this review, we will first discuss the role of EV-associated ncRNAs in different aspects of MM pathobiology, including proliferation, angiogenesis, bone disease development, and drug resistance. Finally, since ncRNAs carried by MM vesicles have also emerged as a promising tool for early diagnosis and therapy response prediction, we will report evidence of their potential use as clinical biomarkers.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-08-01 |