6533b86efe1ef96bd12cb921
RESEARCH PRODUCT
CXCR5 identifies a subset of Vgamma9 Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production.
Nadia Rosalia CaccamoSerena MeravigliaCarmela La MendolaFrancesco DieliAlfredo SalernoL BattistiniM BonnevilleF PocciaJj Fournie'G BorsellinoRa KroczekE Scotetsubject
Vgamma9Vdelta2 T lymphocytes CXCR5 Help B cellsdescription
Vgamma9Vdelta2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-01-01 |