6533b86efe1ef96bd12cbd0a
RESEARCH PRODUCT
A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells
Yulia A. VolkovaAlexander M. ScherbakovDenis Y. UvarovSergey A. GorbatovSergey A. GorbatovAnthony RomieuIgor V. Zavarzinsubject
A549 cell010405 organic chemistryGeneral Chemistry010402 general chemistrymedicine.disease01 natural sciencesFluorescence0104 chemical scienceschemistry.chemical_compoundNitroreductaseWater solublechemistryBiochemistrymedicineBODIPYLung cancerHuman cancerdescription
The development of effective methods for real-time monitoring of nitroreductase (NTR) activity is of great significance for medical diagnosis and cancer research. Here, we present a novel water-soluble BODIPY-based chemodosimeter (NBB) for imaging the hypoxic status of human non-small-cell lung cancer A549 cells. We assume that ‘on–off’ response of NBB is activated by the NTRmediated reductive release of meso-phenol BODIPY dye resulting in unusual fluorescence.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-11-01 | Mendeleev Communications |