Cigarette Smoking is Associated with Decreased Bone Gla-protein (BGP) Levels in Hemodialysis Patients

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RESEARCH PRODUCT

Cigarette Smoking is Associated with Decreased Bone Gla-protein (BGP) Levels in Hemodialysis Patients

Maria Fusaro Fiorenza Magonara Andrea Aghi Giovanni Tripepi Thomas L. Nickolas Antonio Piccoli Mario Plebani Lorenzo A. Calò Nicola Veronese Stefania Sella Giorgio Iervasi Sandro Giannini Michela Spinello Maurizio Gallieni Maria Cristina Mereu Laura Cosmai Fabrizio Fabris Marianna Noale Maria Antonietta Rizzo Andrea Stucchi Alberto Ferraro

subject

Male 0301 basic medicine Vitamin medicine.medical_specialty medicine.medical_treatment Osteocalcin Population Osteoporosis Down-Regulation bone Gastroenterology Cigarette Smoking End stage renal disease 03 medical and health sciences chemistry.chemical_compound Renal Dialysis Risk Factors Internal medicine Humans Medicine Risk factor Vascular Calcification education Aged Pharmacology education.field_of_study Smokers biology business.industry 030111 toxicology BGP Non-Smokers Middle Aged medicine.disease haemodialysi smoke Italy chemistry Osteocalcin biology.protein Kidney Failure Chronic Spinal Fractures Female Hemodialysis Cardiology and Cardiovascular Medicine business Biomarkers Osteoporotic Fractures Calcification

description

Background: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. Methods: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37% (136) smokers (or ex-smokers) and 63% (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. Results: Smokers had significantly lower BGP levels (152 vs. 204 μg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18% (p=0.01). Conclusion: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health. © 2018 Bentham Science Publishers.

year	journal	country	edition	language
2018-01-01	Current Vascular Pharmacology

https://doi.org/10.2174/1570161115666170919182421