Synthesis of new, UV-photoactive dansyl derivatives for flow cytometric studies on bile acid uptake.

6533b86efe1ef96bd12cbdb1

RESEARCH PRODUCT

Synthesis of new, UV-photoactive dansyl derivatives for flow cytometric studies on bile acid uptake.

Miguel A. Miranda M. Teresa Donato Alicia Martínez-romero Jana Rohacova M. Luisa Marin José-enrique O'connor M. José Gómez-lechón José V. Castell

subject

Bile acid transport medicine.drug_class Photochemistry Ultraviolet Rays Kinetics Molecular Conformation Biochemistry Fluorescence Flow cytometry chemistry.chemical_compound fluids and secretions medicine polycyclic compounds Moiety Animals Physical and Theoretical Chemistry Dansyl Compounds Chromatography Bile acid medicine.diagnostic_test Organic Chemistry Cholic acid Cholic Acids Stereoisomerism Flow Cytometry Fluorescence Rats Kinetics chemistry Liver

description

Four new fluorescent derivatives of cholic acid have been synthesized; they incorporate a dansyl moiety at 3 alpha-, 3 beta-, 7 alpha- or 7 beta- positions. These cholic acid analogs are UV photoactive and also exhibit green fluorescence. In addition, they have been demonstrated to be suitable for studying the kinetics of bile acid transport by flow cytometry.

year	journal	country	edition	language
2009-11-13	Organicbiomolecular chemistry

10.1039/b912134j https://pubmed.ncbi.nlm.nih.gov/19907789

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