Combretastatin Analogs via Hydration of Stilbene Derivatives

6533b86efe1ef96bd12cc742

RESEARCH PRODUCT

Combretastatin Analogs via Hydration of Stilbene Derivatives

subject

chemistry.chemical_classification Combretastatin Double bond Organic Chemistry Ether Mass spectrometry Enol Medicinal chemistry Acylation chemistry.chemical_compound chemistry Reagent visual_art visual_art.visual_art_medium Bark Physical and Theoretical Chemistry

description

Hydration of the double bond of some stilbene congeners of Picea abies bark by TiCl4·NaBH4 reagent is described. Five racemic 1,2-diphenylethanol derivatives (9–13), structurally related to (R)-(·)-combretastatin [(R)-1], have been obtained and characterized mainly by 13C- and 1H-NMR as well as mass spectrometry. The antileukemic activity of each compound has preliminarily been tested by the mouse leukemia L1210 system. Compound 10 has been synthesized by Friedel-Crafts acylation.

year	journal	country	edition	language
1993-09-13	Liebigs Annalen der Chemie

https://doi.org/10.1002/jlac.1993199301165

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