Anti-Inflammatory Effects of Onions: Inhibition of Chemotaxis of Human Polymorphonuclear Leukocytes by Thiosulfinates and Cepaenes

6533b86efe1ef96bd12cc7f8

RESEARCH PRODUCT

Anti-Inflammatory Effects of Onions: Inhibition of Chemotaxis of Human Polymorphonuclear Leukocytes by Thiosulfinates and Cepaenes

E. Schneider W. Breu W. Dorsch Hildebert Wagner Thomas Bayer

subject

Adult Neutrophils medicine.drug_class Immunology Inflammation In Vitro Techniques Biology Granulocyte Anti-inflammatory Allium Microbiology medicine Humans Immunology and Allergy Disulfides Thiosulfinate Plant Extracts Liliaceae Anti-Inflammatory Agents Non-Steroidal Chemotaxis General Medicine biology.organism_classification In vitro N-Formylmethionine Leucyl-Phenylalanine Chemotaxis Leukocyte medicine.anatomical_structure Biochemistry Sulfoxides Immunology medicine.symptom

description

Seven different synthetic thiosulfinates, and cepaene- and/or thiosulfinate-rich onion extracts were found to inhibit in vitro the chemotaxis of human granulocytes induced by formyl-methionine-leucinephenylalanine in a dose-dependent manner and at a concentration range of 0.1–100 μ<i>M</i>. Diphenylthiosulfinate showed the highest activity and was found to be more active than prednisolone. The anti-inflammatory properties of onion extracts are related, at least in part, to the inhibition of inflammatory cell influx by thiosulfinates and cepaenes.

year	journal	country	edition	language
1990-01-01	International Archives of Allergy and Immunology

https://doi.org/10.1159/000235221

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