6533b86efe1ef96bd12cc824
RESEARCH PRODUCT
Central motor conduction time by magnetic stimulation of the cortex and peripheral nerve conduction follow-up studies in Friedreich's ataxia.
Francesc PalauCruz-martínez Asubject
AdultMalemedicine.medical_specialtyAtaxiaAdolescentNeural ConductionMotor nerveElectromyographyNerve conduction velocityMagneticsSural NerveTrinucleotide RepeatsInternal medicineCerebellumPhysical StimulationReaction TimeMedicineHumansNeurons AfferentPeripheral NervesChildMuscle SkeletalNeural ConductionMotor Neuronsmedicine.diagnostic_testbusiness.industryElectromyographyGeneral NeurosciencePyramidal CellsMotor CortexMiddle AgedMedian Nervemedicine.anatomical_structureFriedreich AtaxiaPeripheral nervous systemCardiologyDisease ProgressionFemaleNeurology (clinical)medicine.symptomH-reflexbusinessNeuroscienceSensory nerveFollow-Up Studiesdescription
A follow-up clinical study, peripheral motor and sensory nerve conduction velocities and central motor conduction by magnetic stimulation of the cortex were performed in 13 patients with classical Friedreich's ataxia (FA) phenotype, for a period of 9-12 years. Clinical worsening was unrelated to peripheral nerve abnormalities. The amplitude of the nerve action potentials and delayed conduction velocity remained unchanged for several years. Central motor conduction times were abnormal in all patients. Clinical conditions worsened significantly between successive examinations with significant increments in threshold and significant decrement of the amplitude of motor evoked potentials. The results are consistent with progressive pyramidal and cerebellar pathways involvement as the cause of clinical worsening in FA.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-02-04 | Electroencephalography and clinical neurophysiology |