6533b86efe1ef96bd12cc91f
RESEARCH PRODUCT
General Aspects of Metal Ions as Signaling Agents in Health and Disease
Karolina KrzywoszynskaAgnieszka SzebesczykHenryk KozłowskiHenryk KozlowskiDanuta WitkowskaJolanta Swiatek-kozlowskasubject
0301 basic medicineCell signalingProgrammed cell deathMetal ions in aqueous solutionCelllcsh:QR1-502DiseaseReviewBiochemistrySynaptic Transmissionlcsh:Microbiology03 medical and health sciences0302 clinical medicinemedicinecell signaling; metal homeostasis; ferroptosiscell signalingAnimalsFerroptosisHumansMolecular BiologyChemistryFerroptosisCell biology030104 developmental biologymedicine.anatomical_structureMetalsmetal homeostasisSignal transduction030217 neurology & neurosurgeryHomeostasisSignal Transductiondescription
This review focuses on the current knowledge on the involvement of metal ions in signaling processes within the cell, in both physiological and pathological conditions. The first section is devoted to the recent discoveries on magnesium and calcium-dependent signal transduction—the most recognized signaling agents among metals. The following sections then describe signaling pathways where zinc, copper, and iron play a key role. There are many systems in which changes in intra- and extra-cellular zinc and copper concentrations have been linked to important downstream events, especially in nervous signal transduction. Iron signaling is mostly related with its homeostasis. However, it is also involved in a recently discovered type of programmed cell death, ferroptosis. The important differences in metal ion signaling, and its disease-leading alterations, are also discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-10-01 | Biomolecules |