0000000000164370

AUTHOR

Jolanta Swiatek-kozlowska

showing 3 related works from this author

Influence of the position of two dehydro-amino acids residues in the oligopeptide sequence on the binding ability towards Cu(II) ions

2005

Abstract Studies on the binding ability of bis-dehydro-hexa- and pentapeptides have shown that the hexapeptides bind Cu+2 with similar efficacy as pentapeptides. The increase of distance between two dehydro-amino acid residues in the peptide backbone has no impact on the efficacy in metal ion binding. The type of isomeration [(Z) or (E)] has an influence on the coordination of the metal ion only to the first amide nitrogen.

chemistry.chemical_classificationOligopeptideStereochemistrySequence (biology)IonAmino acidInorganic ChemistryMetalchemistry.chemical_compoundBinding abilityCopper(II)Peptide backbonechemistryAmidevisual_artMaterials Chemistryvisual_art.visual_art_mediumdehydro-peptidesOrganic chemistryPhysical and Theoretical ChemistrycomplexPolyhedron
researchProduct

Binding abilities of dehydropeptides towards Cu(II) and Ni(II) ions. Impact of Z–E isomerization on metal ion binding

2002

The study on the binding ability of dehydro-tri- and tetrapeptides has shown that the alpha,beta-double bond has a critical effect on the peptide coordination to metal ions. It may affect the binding of the vicinal amide nitrogens by the electronic effect and stabilize the complex due to steric effects. The (Z) isomer is the most effective in stabilizing of the complexes formed. The presence of large side chain in the dehydroamino acid residue may also be critical for the coordination mode in the metallopeptide systems.

Steric effectsNickel(II) complexesE–Z isomersMetal ion bindingChemistryMetal ions in aqueous solutionPhotochemistryBiochemistryisomerizationInorganic ChemistryMetalCrystallographychemistry.chemical_compounddehydropeptidesAmidevisual_artSide chainvisual_art.visual_art_mediumElectronic effectCopper(II) complexesIsomerizationVicinalJournal of Inorganic Biochemistry : an interdisciplinary journal
researchProduct

General Aspects of Metal Ions as Signaling Agents in Health and Disease

2020

This review focuses on the current knowledge on the involvement of metal ions in signaling processes within the cell, in both physiological and pathological conditions. The first section is devoted to the recent discoveries on magnesium and calcium-dependent signal transduction—the most recognized signaling agents among metals. The following sections then describe signaling pathways where zinc, copper, and iron play a key role. There are many systems in which changes in intra- and extra-cellular zinc and copper concentrations have been linked to important downstream events, especially in nervous signal transduction. Iron signaling is mostly related with its homeostasis. However, it is also …

0301 basic medicineCell signalingProgrammed cell deathMetal ions in aqueous solutionCelllcsh:QR1-502DiseaseReviewBiochemistrySynaptic Transmissionlcsh:Microbiology03 medical and health sciences0302 clinical medicinemedicinecell signaling; metal homeostasis; ferroptosiscell signalingAnimalsFerroptosisHumansMolecular BiologyChemistryFerroptosisCell biology030104 developmental biologymedicine.anatomical_structureMetalsmetal homeostasisSignal transduction030217 neurology & neurosurgeryHomeostasisSignal TransductionBiomolecules
researchProduct