6533b7d9fe1ef96bd126b990
RESEARCH PRODUCT
Binding abilities of dehydropeptides towards Cu(II) and Ni(II) ions. Impact of Z–E isomerization on metal ion binding
Marek ŁUczkowskiMaciej MakowskiJustyna BrasuńJolanta Swiatek-kozlowskasubject
Steric effectsNickel(II) complexesE–Z isomersMetal ion bindingChemistryMetal ions in aqueous solutionPhotochemistryBiochemistryisomerizationInorganic ChemistryMetalCrystallographychemistry.chemical_compounddehydropeptidesAmidevisual_artSide chainvisual_art.visual_art_mediumElectronic effectCopper(II) complexesIsomerizationVicinaldescription
The study on the binding ability of dehydro-tri- and tetrapeptides has shown that the alpha,beta-double bond has a critical effect on the peptide coordination to metal ions. It may affect the binding of the vicinal amide nitrogens by the electronic effect and stabilize the complex due to steric effects. The (Z) isomer is the most effective in stabilizing of the complexes formed. The presence of large side chain in the dehydroamino acid residue may also be critical for the coordination mode in the metallopeptide systems.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-05-29 | Journal of Inorganic Biochemistry : an interdisciplinary journal |