6533b86efe1ef96bd12cca21

RESEARCH PRODUCT

Advanced Glycation End Products: Do They Impair Bone Health in Diabetes?

Papachristou StellaRizzo ManfrediPapanas Nikolaos

subject

Glycation End Products AdvancedDiabetes ComplicationsEndocrinologyBone Densityadvanced glycation end products bone formation complications diabetes mellitusEndocrinology Diabetes and MetabolismReceptor for Advanced Glycation End ProductsDiabetes MellitusInternal MedicineHumansGeneral Medicine

description

AbstractIn diabetes mellitus (DM), there is increased formation and accumulation of advanced glycation end products (AGEs), which represent a heterogeneous class of molecules produced by non-enzymatic glycation of various molecules during long-term hyperglycaemia. Several studies have examined the role of AGEs in DM complications. Accumulating evidence suggests that AGEs affect bone metabolism. New knowledge indicates that they may play a role in bone disease among DM subjects. More data are now needed to clarify their role and to explore new AGEs-based therapeutic options for optimal bone health in DM.

yearjournalcountryeditionlanguage
2022-10-01
10.1055/a-1903-1752https://hdl.handle.net/10447/584514