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RESEARCH PRODUCT
Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography
Salvador SagradoC. Martı́nez-algabaRosa María Villanueva-camañasJ.m. Bermúdez-saldañaM.j. Medina-hernándezsubject
GuaifenesinChlorpheniramineTime FactorsClinical BiochemistryPharmaceutical Science1-PropanolPiperazinesDosage formAnalytical Chemistry1-ButanolChlorcyclizineDrug DiscoverymedicineTriprolidineMicellesSpectroscopyDosage FormsChromatographyCetrimoniumChemistryReproducibility of ResultsBrompheniramineBrompheniraminePromethazinePharmaceutical PreparationsDoxylamineMicellar liquid chromatographyCetrimonium CompoundsHistamine H1 AntagonistsChromatography Liquidmedicine.drugdescription
Rapid chromatographic procedures for analytical quality control of pharmaceutical preparations containing antihistamine drugs, alone or together with other kind of compounds are proposed. The method uses C18 stationary phases and micellar mobile phases of cetyltrimethylammonium bromide (CTAB) with either 1-propanol or 1-butanol as organic modifier. The proposed procedures allow the determination of the antihistamines: brompheniramine, chlorcyclizine, chlorpheniramine, diphenhydramine, doxylamine, flunarizine, hydroxyzine, promethazine, terfenadine, tripelennamine and triprolidine, in addition to caffeine, dextromethorphan, guaifenesin, paracetamol and pyridoxine in different pharmaceutical presentations (tablets, capsules, suppositories, syrups and ointments). The methods require minimum handling sample and are rapid (between 3 and 12 min at 1 mLmin(-1) flow rate) and reproducible (R.S.D. values<5%). Limits of detection are lower than 1 microgmL(-1) and the recoveries of the analytes in the pharmaceutical preparations are in the range 100+/-10%.
year | journal | country | edition | language |
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2005-03-23 | Journal of Pharmaceutical and Biomedical Analysis |