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RESEARCH PRODUCT
Cytotoxic neo-clerodane diterpenes from Stachys aegyptiaca
Ahmed R. HamedAbdelsamed I. ElshamyMohamed-elamir F. HegazyKhaled A. ShamsTarik A. Mohamedsubject
Traditional medicine010405 organic chemistryPlant ScienceDEPT01 natural sciencesBiochemistry0104 chemical sciences010404 medicinal & biomolecular chemistrychemistry.chemical_compoundchemistryClerodane DiterpenesCytotoxic T cellMedicinal herbsDiterpeneAgronomy and Crop ScienceTwo-dimensional nuclear magnetic resonance spectroscopyBiotechnologyStachys aegyptiacadescription
Abstract Two new E/Z neo-clerodane diterpene isomers, trivially named stachaegyptin D (1) and E (2), together with known compounds, stachysolon monoacetate (3) and stachysolon diacetate (4), were isolated from an organic-solvent extract of the medicinal herb Stachys aegyptiaca. Structures were elucidated by a combination of spectroscopic methods, including HREIMS, 1H, 13C, DEPT, and 2D NMR analysis, as well as, first time X-ray analysis for stachysolone (3). All isolated metabolites showed some activity against the human hepatocellular cell line, HepG2. Compound 4 was the most active with an IC50 of 59.5 μM.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-12-01 | Phytochemistry Letters |