Water-soluble magnetic nanoparticles with biologically active stabilizers

6533b86ffe1ef96bd12cd0fc

RESEARCH PRODUCT

Water-soluble magnetic nanoparticles with biologically active stabilizers

Elmars Blums Izolda Segal Mikhail Maiorov Irina Shestakova Alla Zablotskaya Edmunds Lukevics Ilona Domracheva Dmitry Zablotsky

subject

Ferrofluid Iron oxide Nanoparticle Condensed Matter Physics Electronic Optical and Magnetic Materials chemistry.chemical_compound Oleic acid Nuclear magnetic resonance chemistry Magnetic nanoparticles Alkanolamine Iron oxide nanoparticles Magnetite Nuclear chemistry

description

We present the results of the interaction of iron oxide nanoparticles with some biologically active surfactants, namely, oleic acid and cytotoxic alkanolamine derivatives. Physico-chemical properties, as magnetization, magnetite concentration and particle diameter, of the prepared magnetic samples were studied. The nanoparticle size of 11 nm for toluene magnetic fluid determined by TEM is in good agreement with the data obtained by the method of magnetogranulometry. In vitro cytotoxic effect of water-soluble nanoparticles with different iron oxide:oleic acid molar ratio were revealed against human fibrosarcoma and mouse hepatoma cells. In vivo results using a sarcoma mouse model showed observable antitumor action.

year	journal	country	edition	language
2009-05-01	Journal of Magnetism and Magnetic Materials

https://doi.org/10.1016/j.jmmm.2009.02.060

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