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RESEARCH PRODUCT
Nutritional and global indexes of progression in dementia: a 12-month prospective study.
Francesco BolzettaNicola VeroneseMarina De RuiEnzo ManzatoA. GirardiSerena GranzieraAlessandra CoinGiuseppe Sergisubject
Malemedicine.medical_specialtyPediatricsActivities of daily livingMEDLINENutritional StatusNeuropsychological TestsSeverity of Illness Indexnot knownBody Mass IndexSeverity of illnessActivities of Daily LivingMedicineDementiaHumansProspective StudiesProspective cohort studyAgedAged 80 and overMini–Mental State Examinationmedicine.diagnostic_testbusiness.industryGeneral NeuroscienceDisease progressionmedicine.diseasePsychiatry and Mental healthClinical PsychologyPhysical therapyDisease ProgressionDementiaFemaleGeriatrics and GerontologybusinessBody mass indexdescription
Background: To assess the influence of body mass index (BMI) on the progression of dementia. Methods: Sixty elderly outpatients with untreated dementia followed for 12 months. All patients underwent clinical, cognitive, functional, and nutritional assessment at the baseline and after 12 months. Patients were divided into 2 groups by baseline BMI (< or ≥25 kg/m2). Results: Participants with a baseline BMI ≥25 kg/m2 had significantly higher Mini-Mental State Examination (MMSE) scores (21 ± 5.1 vs 15.9 ± 5.5; P < .001), while clinical dementia rating (CDR) and multidimensional prognostic index (MPI) scores were similar in the 2 groups. After 12 months, the MMSE score decreased significantly in both groups compared to the baseline, while the CDR and MPI scores increased significantly for patients with a baseline BMI <25 kg/m2. Conclusion: A BMI cutoff of 25 kg/m2 could be useful for identifying frail patients with dementia who will experience a more rapid global impairment, which could be assessed adequately using multidimensional evaluation tools.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-01 | American journal of Alzheimer's disease and other dementias |