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RESEARCH PRODUCT

Electron microscopic immunogold cytochemistry reveals chromogranin A confined to secretory granules of porcine Merkel cells

Eberhard WeiheUrsula EgnerWolfgang Hartschuh

subject

endocrine systemPathologymedicine.medical_specialtySwineCytoplasmic GranulesCalcium-binding proteinChromograninsmedicineAnimalsSkinintegumentary systembiologyGeneral NeuroscienceChromogranin AImmunogold labellingImmunohistochemistryNeurosecretory SystemsMolecular biologySecretory VesicleMicroscopy Electronmedicine.anatomical_structurebiology.proteinCytochemistryUltrastructureChromogranin AImmunohistochemistryGoldMerkel cell

description

By ultrastructural immunohistochemistry using the immunogold technique, immunoreactive (ir) Chromogranin A (CGA) was found to be confined to the secretory vesicles of porcine Merkel cells. CGA was present predominantly in the periphery of the electron-dense core and on the clear halo. These findings indicate that CGA is a regular constituent of Merkel cell secretory granules but probably not exclusively responsible for their electron opacity.

yearjournalcountryeditionlanguage
1990-08-01Neuroscience Letters
https://doi.org/10.1016/0304-3940(90)90081-j