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RESEARCH PRODUCT

Abnormal Myocardial Perfusion After Infarction in Patients With Persistent TIMI Grade-3 Flow. Only an Acute Phenomenon?

María J. BoschMaria P. Lopez-lereuLuis MainarJulio NúñezVicente BodiOliver HusserEloy DomínguezJuan SanchisÀNgel LlàcerFrancisco J. Chorro

subject

Malemedicine.medical_specialtyTime FactorsSystoleMyocardial InfarctionContrast MediaInfarctionPerfusion scanningMicrocirculationVentricular Dysfunction LeftPolysaccharidesCoronary CirculationInternal medicinemedicineHumanscardiovascular diseasesMyocardial infarctionAgedUltrasonographyEjection fractionVentricular Remodelingmedicine.diagnostic_testbusiness.industryMicrocirculationMagnetic resonance imagingGeneral MedicineMiddle Agedmedicine.diseaseMagnetic Resonance ImagingCardiologyFemalebusinessPerfusionTIMI

description

Introduction and objectives It has been suggested that abnormal perfusion as derived from cardiovascular magnetic resonance imaging (CMR) is a transient dysfunction of microcirculation after myocardial infarction (MI) with TIMI 3 flow. We hypothesized that defects of myocardial perfusion may persist during the following months. Methods Forty-seven patients with MI and sustained TIMI 3 flow underwent intracoronary myocardial contrast echocardiography (MCE) 1 week and 6 months after infarction. Abnormal perfusion by MCE was regarded as >1 hypoperfused segment. Results At one week, 20 patients showed abnormal perfusion as derived from MCE. At six months 10 patients displayed chronic abnormal perfusion. These patients had greater left ventricular volumes and lower ejection fraction at the sixth month by CMR ( P Conclusions MCE detects perfusion defects which can persist in chronic phase–this relates to more severe systolic dysfunction and increased left ventricular volumes.

yearjournalcountryeditionlanguage
2007-05-31Revista Española de Cardiología (English Edition)
https://doi.org/10.1016/s1885-5857(07)60189-3