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RESEARCH PRODUCT

Splenic respiratory gas exchange and glucose uptake in patients with splenomegaly in hypersplenism and Hodgkin's disease.

subject

description

Blood samples are taken from the splenic artery, vein and pulp of patients suffering from Hodgkin's disease (n=10) or hypersplenism (n=7) and undergoing splenectomy. In these samples, the relevant parameters of the respiratory gas exchange as well as glucose and lactate concentrations are determined. In hypersplenism (mean splenic wet weight: 543 g) the mean oxygen consumption of the splenic tissue amounts to 0.9 ml O2/100 g/min taking into account a mean splenic blood flow of 80 ml/100 g/min. The glucose uptake and the lactate release are 9 mg/100 g/min and 5.5 mg/100 g/min, respectively. These values are in close agreement with the results obtained in the normal and undisturbed spleen in situ. In Hodgkin's disease (mean splenic wet weight: 484 g) an increase is occurring in oxygen consumption (\(\dot V_{{\text{O}}_{\text{2}} }\)=1.3 ml O2/100 g/min) and in glucose uptake (\(\dot V_{{\text{G1}}}\)=13 mg/100 g/min). The corresponding lactate release by the splenic tissue into the venous blood is calculated to be 9.6 mg/100 g/min.