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RESEARCH PRODUCT

ChemInform Abstract: Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives.

F. Dean TosteCarlos Del PozoJavier MiróSantos Fustero

subject

Coupling (electronics)ChemistryEnantioselective synthesisCarbonyl derivativesHalogenationchemistry.chemical_elementStereoselectivityGeneral MedicineOxidative phosphorylationCombinatorial chemistryCatalysisPalladium

description

The site-selective palladium-catalyzed three-component coupling of deactivated alkenes, arylboronic acids, and N-fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step-economical approach to the stereoselective β-fluorination of α,β-unsaturated systems.

https://doi.org/10.1002/chin.201650046