0000000000643860

AUTHOR

F. Dean Toste

showing 2 related works from this author

Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives

2016

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The site-selective palladium-catalyzed three-component coupling of deactivated alkenes, arylboronic acids, and N-fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step-economical approach to the stereoselective β-fluorination of α,β-unsaturated systems.

Reaction mechanismHydrocarbons FluorinatedHalogenationStereochemistrychemistry.chemical_elementStereoisomerismAlkenes010402 general chemistry01 natural sciencesArticleCatalysisCatalysisFluorinatedfluorineOrganic chemistrychemistry.chemical_classificationSulfonamidesMolecular StructurealkenesAlkene010405 organic chemistryOrganic ChemistryEnantioselective synthesisHalogenationStereoisomerismGeneral ChemistryGeneral MedicinepalladiumBoronic AcidsHydrocarbons0104 chemical sciencesreaction mechanismschemistryChemical Sciencessynthetic methodsStereoselectivityOxidation-ReductionPalladiumPalladium
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ChemInform Abstract: Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives.

2016

The site-selective palladium-catalyzed three-component coupling of deactivated alkenes, arylboronic acids, and N-fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step-economical approach to the stereoselective β-fluorination of α,β-unsaturated systems.

Coupling (electronics)ChemistryEnantioselective synthesisCarbonyl derivativesHalogenationchemistry.chemical_elementStereoselectivityGeneral MedicineOxidative phosphorylationCombinatorial chemistryCatalysisPalladiumChemInform
researchProduct