Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives

6533b829fe1ef96bd1289891

RESEARCH PRODUCT

Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives

Carlos Del Pozo Santos Fustero Javier Miró F. Dean Toste

subject

Reaction mechanism Hydrocarbons Fluorinated Halogenation Stereochemistry chemistry.chemical_element Stereoisomerism Alkenes 010402 general chemistry 01 natural sciences Article Catalysis Catalysis Fluorinated fluorine Organic chemistry chemistry.chemical_classification Sulfonamides Molecular Structure alkenes Alkene 010405 organic chemistry Organic Chemistry Enantioselective synthesis Halogenation Stereoisomerism General Chemistry General Medicine palladium Boronic Acids Hydrocarbons 0104 chemical sciences reaction mechanisms chemistry Chemical Sciences synthetic methods Stereoselectivity Oxidation-Reduction Palladium Palladium

description

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The site-selective palladium-catalyzed three-component coupling of deactivated alkenes, arylboronic acids, and N-fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step-economical approach to the stereoselective β-fluorination of α,β-unsaturated systems.

year	journal	country	edition	language
2016-06-07

http://www.escholarship.org/uc/item/9zr0s4n4

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