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RESEARCH PRODUCT
Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens
Julia ScholtenDavid VöhringerAri WaismanAnja KöhlerAnke PetzoldClaudia WaskowSangeetha SurianarayananThomas KriegKatrin PeschkeAxel RoersJan DudeckWerner MüllerKarin HartmannAnne DudeckMatthias Gunzersubject
ImmunologyMedizinPriming (immunology)BiologyMicechemistry.chemical_compoundImmune systemAdjuvants ImmunologicCell MovementmedicineAnimalsImmunology and AllergyMast CellsInterleukin 5Allergic contact dermatitisNeovascularization PathologicDendritic CellsHypertrophymedicine.diseaseMast cellImmunity InnateMice Inbred C57BLInterleukin 33Interleukin 10medicine.anatomical_structureInfectious DiseaseschemistryDermatitis Allergic ContactMutationImmunologyLymph NodesHaptensHistamineHistaminedescription
SummaryA prominent feature of sensitizing environmental compounds that cause allergic contact dermatitis is the rapid induction of an innate inflammatory response that seems to provide danger signals for efficient T cell priming. We generated mouse models of mast cell deficiency, mast cell-specific gene inactivation, and mast cell reporter mice for intravital imaging and showed that these adjuvant effects of contact allergens are mediated by mast cells and histamine. Mast cell deficiency resulted in impaired emigration of skin DCs to the lymph node and contact hypersensitivity was dramatically reduced in the absence of mast cells. In addition, mast cell-specific inactivation of the Il10 gene did not reveal any role for mast cell-derived IL-10 in the regulation of contact allergy. Collectively, we demonstrate that mast cells are essential promoters of contact hypersensitivity, thereby highlighting their potential to promote immune responses to antigens entering via the skin.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-06-01 | Immunity |