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RESEARCH PRODUCT
Diverse roles of GSK-3: tumor promoter-tumor suppressor, target in cancer therapy.
Alberto M. MartelliNicole Marie DavisLinda S. SteelmanGiuseppe MontaltoMassimo LibraJörg BäseckeFerdinando NicolettiLucio CoccoMelchiorre CervelloStephen L. AbramsJames A. Mccubreysubject
Cancer ResearchENZYMECarcinogenesisCancer therapymacromolecular substancesBiologymedicine.disease_causeGSK3law.inventionGlycogen Synthase Kinase 3GeneticlawGSK-3NeoplasmsGeneticsmedicineAnimalsHumansGenes Tumor SuppressorGenes tumor suppressorMolecular BiologyGeneCarcinogenesiAnimalNeoplasms therapyMolecular medicineMetabolismCancer researchNeoplasmMolecular MedicineSuppressorCarcinogenesisGlycogenHumandescription
Glycogen synthase kinase-3 (GSK-3) is a critical enzyme which participates in a complex array of important cellular processes and is often involved in various human diseases. It was first characterized in rat skeletal muscle as a serine/threonine (S/T) kinase that phosphorylated and inactivated glycogen synthase (GS). GS is the last enzyme in glycogen biosynthesis . Thus the initially identified role of GSK-3 was in metabolism. However, as we will soon see, GSK-3 has many diverse functions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-08-25 | Advances in biological regulation |