6533b86ffe1ef96bd12cdd75

RESEARCH PRODUCT

Bemiparin improves the total antioxidant status in plasma

Juan GambiniVerónica PlanellesElena DomenechJosé García-de-la-asunciónJavier BeldaPaula De ToroJaime Perez-griera

subject

AdultMaleAntioxidantmedicine.medical_treatmentPharmacologymedicine.disease_causeAntioxidantsSuperoxide dismutasechemistry.chemical_compoundBlood plasmamedicineHumansPharmacologychemistry.chemical_classificationGlutathione PeroxidasebiologySuperoxide DismutaseGlutathione peroxidaseHeparin Low-Molecular-WeightMalondialdehydeOxidative StressAntioxidant capacityEnzymeBiochemistrychemistryHealthbiology.proteinFemaleBiomarkersOxidative stress

description

The aim of this work is to test the protective effect of bemiparin (3500 I.U., s.c.) against oxidative stress in plasma from healthy volunteers. We have evaluated the total antioxidant activity in plasma, superoxide dismutase and glutathione peroxidase activities, and oxidized glutathione and malondialdehyde levels, in two groups: treated (n=20) and control (n=15). Blood samples were collected at: basal, 2, 4, 6, 8 and 10 h. Total antioxidant activity and antioxidant enzymes activity were higher in the treated group at 2-6 h. However, oxidized glutathione and malondialdehyde levels were lower in the treated group at same times. The results suggest that bemiparin exerts an early beneficial effect against oxidative stress in plasma.

yearjournalcountryeditionlanguage
2008-08-20European Journal of Pharmacology
https://doi.org/10.1016/j.ejphar.2008.11.042