6533b86ffe1ef96bd12cddf5

RESEARCH PRODUCT

Antioxidant Profile of Mono-and Dihydroxylated Flavone Derivatives in Free Radical Generating Systems

María Carmen TerencioMaría Carmen MontesinosAmalia UbedaMaría José AlcarazMiguel Payá

subject

MaleAntioxidantFree RadicalsNeutrophilsStereochemistrymedicine.medical_treatmentIn Vitro TechniquesHydroxylationFlavonesAntioxidantsGeneral Biochemistry Genetics and Molecular BiologyLipid peroxidationStructure-Activity Relationshipchemistry.chemical_compoundSuperoxidesmedicineAnimalsHumansOrganic chemistryRats WistarFlavonoidschemistry.chemical_classificationMolecular StructureHydroxyl RadicalChemistrySuperoxideFlavone derivativesFree Radical ScavengersPeroxidesRatsPeroxyl radicalsMicrosomes LiverMicrosomeHydroxyl radicalLipid PeroxidationNADP

description

Abstract A number of free radical generating systems were used to investigate the antioxidant properties and structure-activity relationships of a series of monohydroxylated and dihydrox­ylated flavones. Ortho-dihydroxylated flavones showed the highest inhibitory activity on en­ zymic and non-enzymic microsomal lipid peroxidation as well as on peroxyl radical scaveng­ing. Most flavones were weak scavengers of hydroxyl radical, while ortho-dihydroxylated flavones interacted with superoxide anion generated by an enzymic system or by human neutrophils. This series of compounds did not exert cytotoxic effects on these cells. Scaveng­ing of superoxide and peroxyl radicals may determ ine the antioxidant properties of these active flavones.

yearjournalcountryeditionlanguage
1995-08-01Zeitschrift für Naturforschung C
https://doi.org/10.1515/znc-1995-7-813