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RESEARCH PRODUCT
Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity
Donna K. ArnettCaren E. SmithYu-chi LeeChao-qiang LaiStella AslibekyanDevin AbsherMichael A. ProvincePaul N. HopkinsDolores CorellaBertha HidalgoJose M. OrdovasJose M. OrdovasJose M. OrdovasLaurence D. ParnellKatherine L. Tuckersubject
EpigenomicsMale0301 basic medicineGenotypeMedicine (miscellaneous)030204 cardiovascular system & hematologyBiologyBioinformatics03 medical and health sciences0302 clinical medicineFramingham Heart StudyMetabolomicsGenotypemedicineHumansMetabolomicsDrug InteractionsObesityEpigeneticsAgedEpigenomicsNutrition and DieteticsApolipoprotein A-Ifood and beveragesGenetic VariationEpigenomeDNA MethylationMiddle AgedLipid Metabolismmedicine.diseaseDietary FatsObesityOriginal Research Communications030104 developmental biologyGene Expression RegulationSaturated fatty acidCpG IslandsFemaleApolipoprotein A-IIdescription
BACKGROUND: The putative functional variant −265T>C (rs5082) within the APOA2 promoter has shown consistent interactions with saturated fatty acid (SFA) intake to influence the risk of obesity. OBJECTIVE: The aim of this study was to implement an integrative approach to characterize the molecular basis of this interaction. DESIGN: We conducted an epigenome-wide scan on 80 participants carrying either the rs5082 CC or TT genotypes and consuming either a low-SFA (C genotype, promoting an APOA2 expression difference between APOA2 genotypes on a high-SFA diet, and modulating BCAA and tryptophan metabolic pathways. These findings identify potential mechanisms by which this highly reproducible gene-diet interaction influences obesity risk, and contribute new insights to ongoing investigations of the relation between SFA and human health. This study was registered at clinicaltrials.gov as NCT03452787.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-07-01 | The American Journal of Clinical Nutrition |