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RESEARCH PRODUCT

In-hospital outcomes and 5-year mortality following an acute myocardial infarction in patients with a history of cancer: Results from the French registry on Acute ST-elevation or non-ST-elevation myocardial infarction (FAST-MI) 2005 cohort

Nadia AissaouiTabassome SimonJean FerrièresAlain FurberMeyer ElbazFranck BoccaraDenis AngoulvantStéphane EderhyPhilipe DruellesAriel CohenFrancois SchieleFast-mi InvestigatorsStephane AndrieuE. Bonnefoy-cudrazNicolas DanchinEtienne PuymiratYves Cottin

subject

Malemedicine.medical_specialtyTime Factors[SDV]Life Sciences [q-bio]Infarctus du myocardeAcute myocardial infarction030204 cardiovascular system & hematologyMortalitéRisk AssessmentCoronary artery disease03 medical and health sciences0302 clinical medicineRisk FactorsNeoplasmsInternal medicineMortalité hospitalière.medicineHumansMedical historyHospital MortalityProspective StudiesRegistries030212 general & internal medicineMyocardial infarctioncardiovascular diseasesRisk factorMortalityNon-ST Elevated Myocardial InfarctionAgedCancerAged 80 and overbusiness.industryST elevationHazard ratioGeneral MedicineOdds ratioMiddle Agedmedicine.disease3. Good healthHospitalization[SDV] Life Sciences [q-bio]In-hospital mortalityTreatment OutcomeCohortST Elevation Myocardial InfarctionFemaleFranceCardiology and Cardiovascular Medicinebusiness

description

Summary Background Cancer and acute myocardial infarction (AMI) have important prognostic consequences. Treatment of some cancers may affect coronary artery disease, myocardial function and/or AMI management. Whether the early and long-term mortality of patients with AMI differ according to their history of cancer remains questionable. Aims To determine in-hospital outcomes and 5-year mortality following AMI according to patient history of cancer. Methods The FAST-MI registry is a nationwide French survey collecting data on characteristics, management and outcomes of 3670 consecutive patients admitted for AMI during October 2005. Results Overall, 246/3664 patients (6.7%) admitted for an AMI (47.6% with ST-segment elevation myocardial infarction [STEMI]; 52.4% with non-STEMI [NSTEMI]) had a history of cancer. In-hospital mortality was not significantly different for patients with versus without a history of cancer, overall (adjusted odds ratio [OR]: 1.15, 95% confidence interval [CI]: 0.68–1.94; P = 0.61) and in patients with STEMI (adjusted OR: 1.37, 95% CI: 0.69–2.71; P = 0.37) or NSTEMI (adjusted OR: 0.97, 95% CI: 0.41–2.28; P = 0.95). All-cause mortality at 5 years was higher among patients with a history of cancer (adjusted hazard ratio [HR]: 1.36, 95% CI: 1.08–1.69; P = 0.008), whereas 5-year cardiovascular mortality did not differ (adjusted HR: 1.17, 95% CI: 0.89–1.53; P = 0.25), regardless of whether the patients had STEMI or NSTEMI. Similar results were found in populations matched on a propensity score including baseline characteristics and early management. Conclusion A history of cancer, per se, does not appear to be a risk factor for increased in-hospital mortality or long-term cardiovascular mortality in patients admitted for AMI.

yearjournalcountryeditionlanguage
2019-11-01
10.1016/j.acvd.2019.06.012https://doi.org/10.1016/j.acvd.2019.06.012