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RESEARCH PRODUCT
Immunohistochemical detection of early myocardial infarction: a systematic review
Luigi CardiaElvira Ventura-spagnoloCristina Mondellosubject
Pathologymedicine.medical_specialty2734Myocardial InfarctionIschemia030204 cardiovascular system & hematologyPathology and Forensic MedicineSudden cardiac death03 medical and health sciences0302 clinical medicineSettore MED/43 - Medicina LegaleHistological diagnosisEarly myocardial infarctionmedicineAnimalsHumans030216 legal & forensic medicineMyocardial infarctionEarly myocardial infarction; Immunohistochemistry; Sudden cardiac death; Systematic review; Animals; Biomarkers; Death Sudden Cardiac; Forensic Pathology; Humans; Immunohistochemistry; Myocardial Infarction; 2734Forensic PathologyPostmortem DiagnosisAnimalbusiness.industryEarly myocardial infarction Immunohistochemistry Sudden cardiac Death Systematic reviewBiomarkermedicine.diseaseImmunohistochemistrySudden cardiac deathDeath Sudden CardiacHeart failureInclusion and exclusion criteriaSystematic reviewImmunohistochemistrybusinessBiomarkersHumandescription
The postmortem diagnosis of early myocardial infarction is a challenge for forensic pathologists because the routine histology is neither specific. Many authors have suggested the use of the immunohistochemistry to fill the gaps in the histological diagnosis of early myocardial infarction. This review aims to analyse advances of immunohistochemical detection of early cardiac damage due to ischaemia. To this purpose, we reviewed experimental studies that investigated immunohistochemical markers and their estimated timing of expression. The review was performed according to specific inclusion and exclusion criteria, and a total of 23 studies assessing the immunohistochemical markers for the diagnosis and timing of early myocardial infarction were identified. The literature review highlights that the analysed markers are complement components, others being inflammatory mediators, cardiac cell proteins, plasma proteins, stress or hypoxia-induced factors and proteins associated with heart failure. All studies demonstrate the effectiveness of the tested markers in the early detection of myocardial infarction in both animal and human samples.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 | International Journal of Legal Medicine |