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RESEARCH PRODUCT
Influences of prenatal and postnatal stress on adult hippocampal neurogenesis: The double neurogenic niche hypothesis
Sylvia Ortega-martínezsubject
MaleAgingBrain developmentprogenitor cellNeurogenesisNicheAdult hipocampal neurogenesis (AHN)neural stem-cellHippocampal formationgrowth-factorHippocampusHypothalamic-pituitary-adrenal (HPA)03 medical and health sciencesBehavioral Neuroscience0302 clinical medicinePregnancyRisk FactorsPrecursor cellPostnatal stressAnimalsHumanspattern separation030304 developmental biologyCell Proliferationrat dentate gyrus0303 health sciencesMental DisordersNeurogenesisStressorsubventricular zoneCell DifferentiationPrecursor cellsPostnatal stress (PTS)Neurogenic poolgenetic influencePrenatal Exposure Delayed Effectsolfactory-bulbPrenatal stress (PS)Female[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]decreases neurogenesisPsychologyNeuroscience030217 neurology & neurosurgeryStress Psychologicalbrain neurogenesisdescription
International audience; Adult hippocampal neurogenesis (AHN) is involved in learning, memory, and stress, and plays a significant role in neurodegenerative and psychiatric disorders. As an age-dependent process, AHN is largely influenced by changes that occur during the pre- and postnatal stages of brain development, and constitutes an important field of research. This review examines the current knowledge regarding the regulators of AHN and the influence of prenatal and postnatal stress on later AHN. In addition, a hypothesis is presented suggesting that each kind of stress influences a specific neurogenic pool, developmental or postnatal, that later becomes a precursor with important repercussions for AHN. This hypothesis is referred to as "the double neurogenic niche hypothesis." Discovering what receptors, transcription factors, or genes are specifically activated by different stressors is proposed as an essential line of future research in the field. Such knowledge shall constitute an important starting point toward the goal of modifying AHN in neurodegenerative or psychiatric diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 |