Search results for "Niche"
showing 10 items of 1201 documents
Wireless ECG and cardiac monitoring systems: State of the art, available commercial devices and useful electronic components
2021
Abstract Wireless ElectroCardioGram (ECG) systems are employed in manifold application fields: tele-monitoring, sport applications, support to ageing people at home, fetal ECG, wearable devices and ambulatory monitoring. The presence of cables often hinders user’s free movements, alongside clinicians’ routine operations. Therefore, wireless ECG systems are desirable. This paper aims at reviewing the solutions described in the literature, besides commercially available devices and electronic components useful to setup laboratory prototypes. Several systems have been developed, different in terms of the adopted technology; when approaching the development of a wireless ECG system, some import…
Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception
2016
Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells and neural stem cells (NSCs) of the SVZ to shape the vascular stem-cell niche. Loss of EGFL7 causes an accumulation of activated NSCs, which display enhanced activity and re-entry into the cell cycle. EGFL7 pushes activated NSCs towards quiescence and neuronal progeny towards differentiation. This is achieved by promoting Dll4-induced Notch signalling at the blood vessel-stem …
The International Guideline Evaluation Screening Tool (IGEST): development and validation.
2022
Abstract Background Guideline adaptation provides an important alternative to de novo guideline development by making the process more efficient and reducing unnecessary duplication. The quality evaluation of international guidelines is an essential part of the adaptation process. The study aims at describing the development and validation of a new tool to screen trustworthy Clinical Practice Guidelines (CPGs) for their adoption/adaption: the International Guideline Evaluation Screening Tool (IGEST). Methods The process of developing the IGEST involved two main phases: 1) tool development and 2) content validation. The tool development phase comprised three stages, where the scope of the IG…
High Resolution CT Angiography in Detection of an Aneurysm of the Vein of Galen as a Source of Intracranial Haemorrhage in a Newborn.
2011
Cerebral haemorrhage is a rare condition in infants and carries a known poor prognosis. Common causes of spontaneous haemorrhage include various vascular venous lesions due to incomplete hydrovenous maturation, among them Galen vein aneurysm may be a very rare cause of cerebral haemorrhage. This report emphasizes the role of multidector CT with high resolution CT angiography in a newborn with cerebral hemorrhage caused by Galen vein aneurysm rupture. MDCT with high resolution CT angiography helps to differentiate the cause of haemorrhage, and to address the appropriate treatment.
Will the invasive western conifer seed bug Leptoglossus occidentalis Heidemann (Hemiptera: Heteroptera: Coreidae) seize all of Europe?
2008
In our day, thanks to high-speed transport systems, people are moving living species (intentionally or not) across ecosystems and countless borders. As we know, most introduced species usually do not survive, because they find neither a tolerable environment nor an available ecological niche. Sometimes, successful establishment may also require multiple introductions (Balcom 2004).
Uncertainty management in the measurements of low frequency magnetic fields
2014
The paper deals with low-frequency magnetic field measurements carried out by using a broadband and isotropic instrument. These measurements are characterized by very high uncertainty values, which imply a high risk of wrong decisions when there is the need to establish if a site complies or does not comply with specified emission limits. To reduce this risk, we decided to perform the so called “uncertainty management” that is the discipline of optimizing the cost of a measurement versus the uncertainty target. The task is achieved by using the PUMA method that is an iterative technique originally conceived for geometrical and mechanical measurements. The approach is completely based on the…
A prototypal architecture of a IEEE 21451 network for smart grid applications based on power line communications
2015
This paper deals with the development of reliable measurement and communication devices and systems and their integration on a prototypal network architecture for smart grid applications, based on the use of narrowband power line communications (PLCs). The proposed solution is presented and discussed in the framework of the ISO/IEC/IEEE 21451 family of Standards. Currently, PLCs are not properly addressed by the aforesaid Standards; on the other hand, by including such issue, their guidelines could represent a common platform for the integration and interoperability of the proposed systems and devices. This would allow to exploit the benefits of the IEEE 21451 approach also for PLC-based sm…
Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow
2014
How stem cells interact with the microenvironment to regulate their cell fates and metabolism is largely unknown. Here we demonstrated that the deletion of the cytoskeleton-modulating protein profilin 1 (pfn1) in hematopoietic stem cell (HSCs) led to bone marrow failure, loss of quiescence, and mobilization and apoptosis of HSCs in vivo. A switch from glycolysis to mitochondrial respiration with increased reactive oxygen species (ROS) level was also observed in HSCs on pfn1 deletion. Importantly, treatment of pfn1-deficient mice with the antioxidant N-acetyl-l-cysteine reversed the ROS level and loss of quiescence of HSCs, suggesting that the metabolism is mechanistically linked to the cell…
From clear lakes to murky waters – tracing the functional response of high-latitude lake communities to concurrent ‘greening’ and ‘browning’
2019
Climate change and the intensification of land use practices are causing widespread eutrophication of subarctic lakes. The implications of this rapid change for lake ecosystem function remain poorly understood. To assess how freshwater communities respond to such profound changes in their habitat and resource availability, we conducted a space-for-time analysis of food-web structure in 30 lakes situated across a temperature-productivity gradient equivalent to the predicted future climate of subarctic Europe (temperature +3 degrees C, precipitation +30% and nutrient +45 mu g L-1 total phosphorus). Along this gradient, we observed an increase in the assimilation of pelagic-derived carbon from…
Metrological performances of voltage and current instrument transformers in harmonics measurements
2018
In the new electrical system scenario, the increasing presence of non-linear loads and renewable energy sources makes the measurement of harmonics an essential task. The accuracy of harmonic measurement firstly depends on the used instrument transformers for voltage and current sensing. Since the behavior of instrument transformers in non-sinusoidal conditions is not always well defined, this paper presents an experimental study on the metrological performances of current and voltage instrument transformers (CTs and VTs) in the presence of harmonics. Proper tests procedures are defined and measurement setups are developed for both CTs and VTs calibration. The analysis is carried out by usin…