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RESEARCH PRODUCT
Treatment-resistant depression in a real-world setting: first interim analysis of characteristics, healthcare resource use, and utility values of the fondaMental cohort
Pierre-michel LlorcaSophie MarguetRaphaëlle RichieriVincent CamusDominique SchaetzEmmanuel HaffenAntoine YrondiChristophe LançonJean-baptiste GentyMathilde HornJulia MaruaniThierry BougerolMarion LeboyerDjamila BennabiPhilippe CourtetRémi MoirandNathalie DennisLaurent SchmittEtienne AllauzeIsabel NietoWissam El-hageJérôme HoltzmannDamien PierreFanny MoliereFlorian StephanGuillaume VaivaOlivier DoumyMichel WalterLudovic SamalinThierry D'amatoBruno AouizerateDelphine Quelardsubject
medicine.medical_specialtyreal-world[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthArticlelcsh:RC321-57103 medical and health sciences0302 clinical medicinehealthcare resource useQuality of lifeRating scaleInternal medicineMedicine[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Major depressive episodelcsh:Neurosciences. Biological psychiatry. NeuropsychiatryDepression (differential diagnoses)business.industryGeneral Neurosciencemedicine.diseaseInterim analysis3. Good health030227 psychiatryutility[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthCohorttreatment-resistant depressionMajor depressive disorder[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC][SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologiemedicine.symptombusinessTreatment-resistant depression030217 neurology & neurosurgerydescription
Background: Major depressive disorder (MDD) is among the most common psychiatric disorders. One-third of patients are usually unresponsive to several lines of treatment. This study aimed to describe the FondaMental French cohort of patients with treatment-resistant depression (TRD) and to estimate utility and healthcare resource use outcomes. Methods: Patients with TRD were evaluated prospectively over four years (baseline, 6, 12, 18, 24, 36 and 48 months) in a real-world clinical setting. Interim analyses focused on the first two consecutive years. Four MDD-related states (major depressive episode (MDE), response, remission, recovery) were defined based on the MADRS (Montgomery&ndash
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-12-10 |