6533b86ffe1ef96bd12ce5b0
RESEARCH PRODUCT
Topical Anti-Inflammatory Lignans from Haplophyllum hispanicum Haplophyllum hispanicum
José-luis RíosA. MassmanianSalvador MáñezMaría-carmen RecioRosa-maría GinerJose M. PrietoPeter G. Watermansubject
chemistry.chemical_compoundHeteronuclear moleculechemistryStereochemistryEdemaArylmedicineDiphyllin acetyl apiosidemedicine.symptomCarbon-13 NMRTopical anti-inflammatoryGeneral Biochemistry Genetics and Molecular Biologydescription
The present paper reports the results of the methanol extract of Haplophyllum hispanicum Spach on single or repeated local 12-O-tetradecanoylphorbol acetate (TPA) administration and in the oxazolone-induced contact-delayed hypersensitivity mouse ear edemas. Two topical anti-inflammatory aryl naphthalide lignans were isolated from the active fractions of the methanol extract. They were identified by spectroscopic methods, including 13C NMR and heteronuclear multiple bond correlation (HMBC), as diphyllin acetyl apioside and tuberculatin. The former was the most active on acute TPA edema with a ID50 of 0.27 μmol/ear
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-10-01 | Zeitschrift für Naturforschung C |