6533b86ffe1ef96bd12ce651
RESEARCH PRODUCT
Synthesis of C1-[18F]fluoroethylamnino asparagine for imaging cancer
Peter BartensteinRalf SchirrmacherGregor J. FörsterB. WolfFrank Röschsubject
chemistry.chemical_classificationChemistryStereochemistryOrganic ChemistryCancermedicine.diseaseBiochemistryIn vivo testsAnalytical ChemistryAmino acidchemistry.chemical_compoundYield (chemistry)Drug DiscoverymedicineOrganic chemistryRadiology Nuclear Medicine and imagingAsparagineFluorideSpectroscopydescription
C1-[18F]fluoroethylamino asparagine was synthesised from N1-t-boc C1-p-nitrophenol asparagine and the radiolabelled precursor [18F]flouroethylamine in a one-pot-synthesis. The yield of this synthesis was 22% referring to [18F]fluoride, including the removal of the protection groups. The in vivo tests are in progress.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-05-01 | Journal of Labelled Compounds and Radiopharmaceuticals |