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RESEARCH PRODUCT
Cover Picture: Direct CH Metalation with Chromium(II) and Iron(II): Transition-Metal Host / Benzenediide Guest Magnetic Inverse-Crown Complexes (Angew. Chem. Int. Ed. 18/2009)
Jan KlettPablo García-álvarezEva RentschlerAlan R. KennedyLuca RussoPablo AlborésRobert E. MulveyLuca M. CarrellaWilliam Cleggsubject
MetalationSodiumInorganic chemistrychemistry.chemical_elementGeneral ChemistryAlkali metalMedicinal chemistryCatalysisChromiumchemistry.chemical_compoundDeprotonationchemistryTransition metalReactivity (chemistry)Benzenedescription
Chromation and ferration are the latest additions to the concept of alkali-metal-mediated metalation, as described by J. Klett, R. E. Mulvey, and co-workers in their Communication on page 3317 ff. While the more electropositive sodium is essential for the reaction, it is the less electropositive chromium or iron that actually performs deprotonation of benzene. This novel reactivity can be likened to a game of chess in which the queen (Na) holds the king in check, while the knight (Cr, Fe) scores checkm(etal)ate.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-04-20 | Angewandte Chemie International Edition |