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RESEARCH PRODUCT

Epicardial Adipose Tissue Accumulation and Essential Hypertension in Non-Obese Adults

Andrej DobrovolskijAndrej DobrovolskijNomeda Rima ValevičienėRimantas StukasValerija JablonskienėValerij DobrovolskijDonatas Austys

subject

AdultMale0301 basic medicineMedicine (General)medicine.medical_specialtyepicardial fatBlood Pressure030204 cardiovascular system & hematologyEssential hypertensionArticleBody Mass IndexCoronary artery disease03 medical and health sciencesR5-9200302 clinical medicineNon obeseCardiac magnetic resonance imagingInternal medicinegrade of hypertensionmedicineepicardial fat ; primary hypertension ; grade of hypertension ; risk assessment ; adultsadultsHumansAged2. Zero hungermedicine.diagnostic_testAdult patientsbusiness.industryrisk assessmentGeneral MedicineMiddle Agedmedicine.diseasePathophysiology3. Good healthprimary hypertension030104 developmental biologyAdipose TissueEpicardial adipose tissueCardiologyepicardial fat; primary hypertension; grade of hypertension; risk assessment; adultsFemaleEssential HypertensionbusinessPericardiumBody mass index

description

Background and Objectives: Epicardial adipose tissue (EAT) is shown to be an important factor in the development of coronary artery disease, but numerous pathophysiological mechanisms of its action are still only partially understood. There is a lack of studies on its association with different grades of essential hypertension (EH). Therefore, we aimed to evaluate the association between size of EAT depots and the risk of EH taking into account its grade. Materials and Methods: Non-obese adult patients with various cardiovascular diseases were investigated: 157 of them had essential hypertension and 101 did not. Hypertensive patients were assigned to three groups according to the grade of hypertension. EAT volume and thickness on ventricular free walls (6 locations) and grooves (5 locations) were measured using cardiac magnetic resonance imaging and compared between groups. A regression model for the prediction of EH was constructed. Results: In general, thickness (in all locations) and volume of EAT depots was greater among hypertensive patients than in normotensive (NORM) group. Mean EAT thickness in all 11 locations and EAT volume were lower in NORM than in grade 1 hypertension group

yearjournalcountryeditionlanguage
2019-08-09Medicina
10.3390/medicina55080456http://dx.doi.org/10.3390/medicina55080456