6533b86ffe1ef96bd12ce7e9

RESEARCH PRODUCT

Overdose of Quetiapine—A Case Report with QT Prolongation

Elisabetta BertolFabio VaianoAntonina ArgoStefania ZerboClaudia TrignanoSimone ProtaniDonata Favretto

subject

Chemical Health and SafetySettore MED/43 - Medicina LegaleintoxicationChemical technologyHealth Toxicology and MutagenesisSettore BIO/14 - FarmacologiaCase ReportTP1-1185quetiapineToxicologySettore MED/25 - PsichiatriaIntoxication; QT-prolongation; QuetiapineQT-prolongation

description

Quetiapine is an atypical antipsychotic drug used to treat bipolar disorder, schizophrenia, and major depressive disorder. Although several studies describe the adverse effects of intoxication with Quetiapine, only a few report an extreme overdose without comedications that lead to a life threat. We present a case of a 75-year-old male who tried to attempt suicide by ingesting 28 g of Quetiapine. During the management in the emergency department, both serum and urine samples were collected, allowing a complete pharmacokinetic analysis to be conducted, from the admission to the discharge.

yearjournalcountryeditionlanguage
2021-12-01Toxics
https://doi.org/10.3390/toxics9120339