0000000001029732

AUTHOR

Claudia Trignano

0000-0002-8846-0700

showing 2 related works from this author

A Forensic Diagnostic Algorithm for Drug-Related Deaths: A Case Series

2022

The best evidence provided in the literature worldwide suggests the importance of harmonizing the investigation in drug-related fatalities. In this study, the application of a multidisciplinary approach in eight cases of drug-related deaths is presented. Although death scene findings could be highly suggestive of drug intoxication, external examination and toxicological screening test alone are insufficient. There are several variables, and it is not always easy to give the proper interpretation of the drug detection. A complete autopsy is necessary to correctly complete organ and tissues sampling for further histological and toxicological studies and obtain body fluids. The use of peripher…

drug intoxication diagnosisdrug-related deaths; forensic diagnosis; diagnostic algorithm; drug intoxication diagnosisChemical Health and SafetySettore MED/43 - Medicina LegaleHealth Toxicology and Mutagenesisdrug-related deathSettore BIO/14 - FarmacologiaSettore MED/05 - Patologia Clinicaforensic diagnosiToxicologydiagnostic algorithmToxics
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Overdose of Quetiapine—A Case Report with QT Prolongation

2021

Quetiapine is an atypical antipsychotic drug used to treat bipolar disorder, schizophrenia, and major depressive disorder. Although several studies describe the adverse effects of intoxication with Quetiapine, only a few report an extreme overdose without comedications that lead to a life threat. We present a case of a 75-year-old male who tried to attempt suicide by ingesting 28 g of Quetiapine. During the management in the emergency department, both serum and urine samples were collected, allowing a complete pharmacokinetic analysis to be conducted, from the admission to the discharge.

Chemical Health and SafetySettore MED/43 - Medicina LegaleintoxicationChemical technologyHealth Toxicology and MutagenesisSettore BIO/14 - FarmacologiaCase ReportTP1-1185quetiapineToxicologySettore MED/25 - PsichiatriaIntoxication; QT-prolongation; QuetiapineQT-prolongationToxics
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