6533b86ffe1ef96bd12ce810
RESEARCH PRODUCT
Exhaled nitric oxide is associated with cyclic changes in sexual hormones
Scichilone NicolaStefania MenoniFulvio BraidoSalvatore BattagliaRita ArrigoVincenzo BelliaAlida BenfanteAntonella Collurasubject
AdultPulmonary and Respiratory Medicinemedicine.medical_specialtymedia_common.quotation_subjectReproductive ageBronchiSettore MED/10 - Malattie Dell'Apparato RespiratorioNitric OxideNitric oxidechemistry.chemical_compoundsexual hormonesInternal medicinemedicineHumansPharmacology (medical)SalivaGeneralized estimating equationMenstrual cycleMenstrual CycleProgesteronemedia_commonEstradiolbusiness.industryBiochemistry (medical)GenderBiomarkerHormonesSexual hormonesPulmonary AlveoliEndocrinologychemistryBreath TestsNon allergicExhaled nitric oxideAirway inflammation; Biomarker; Gender; Hormones; Adult; Breath Tests; Bronchi; Estradiol; Female; Humans; Menstrual Cycle; Nitric Oxide; Progesterone; Pulmonary Alveoli; Saliva; Pulmonary and Respiratory Medicine; Pharmacology (medical); Biochemistry (medical)FemalebusinessHormoneAirway inflammationdescription
Abstract Background We hypothesized that changes in the levels of sexual hormones during the menstrual cycle influence the concentration of nitric oxide in the exhaled air (FeNO) and alveolar exhaled nitric oxide (CANO). Methods Twelve healthy, non allergic women in their reproductive age (age range 25–37 years) were recruited. Subjects were studied, on alternate days, over the course of their menstrual cycle. At each visit, measurements of FeNO and CANO were performed. Progesterone and 17-β-estradiol concentrations were measured in salivary samples. Results Eight subjects completed the study. The levels of FeNO and CANO were 13 ± 4.7 pbb and 3.5 ± 1.9 pbb, respectively (mean ± SD). The mean salivary concentration of progesterone was 65.1 ± 16.2 pg/ml (mean ± SD), with a range of 32.4–107.7 pg/ml, and the concentration of 17 β-estradiol was 6.0 ± 1.6 pg/ml, with a range of 3.1–12.9 pg/ml. The Generalized Estimating Equations procedure demonstrated that levels of progesterone influenced both FeNO and CANO (Wald χ2 = 11.60, p = 0.001; and Wald χ2 = 87.55, p = 0.001, respectively). On the contrary, the salivary levels of 17 β-estradiol were not significantly associated with FeNO (Wald χ2 = 0.087, p = 0.768) or CANO (Wald χ2 = 0.58, p = 0.448). Conclusion In healthy women, the menstrual cycle-associated hormonal fluctuations selectively influence the levels of bronchial and alveolar NO. The current findings may have important clinical implications for the interpretation of eNO levels, by identifying a patient-related factor that influences the eNO measurements.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 |