Optimization of Innovative Three-Dimensionally-Structured Hybrid Vesicles to Improve the Cutaneous Delivery of Clotrimazole for the Treatment of Topical Candidiasis

6533b86ffe1ef96bd12ce819

RESEARCH PRODUCT

Optimization of Innovative Three-Dimensionally-Structured Hybrid Vesicles to Improve the Cutaneous Delivery of Clotrimazole for the Treatment of Topical Candidiasis

Anna Maria Fadda Maria Manconi Antonella Ibba José Esteban Peris Francisco J. Aranda Donatella Valenti Juan C. Gómez-fernández Elvira Escribano-ferrer Maria Letizia Manca Germano Orrù Iris Usach

subject

Phospholipid Pharmaceutical Science lcsh:RS1-441 02 engineering and technology 030226 pharmacology & pharmacy Article clotrimazole lcsh:Pharmacy and materia medica 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo phospholipid vesicles X-rays Candida albicans Electron microscopy medicine Glycerol skin delivery Candida albicans co-solvents Phospholipids Chromatography biology Clotrimazole Small-angle X-ray scattering Vesicle 021001 nanoscience & nanotechnology biology.organism_classification <i>Candida albicans</i>Microscòpia electrònica chemistry Transmission electron microscopy fungal infections Raigs X 0210 nano-technology Fosfolípids medicine.drug

description

New three-dimensionally-structured hybrid phospholipid vesicles, able to load clotrimazole in a high amount (10 mg/mL), were obtained for the first time in this work by significantly reducing the amount of water (&le

year	journal	country	edition	language
2019-06-01	Pharmaceutics

10.3390/pharmaceutics11060263 https://www.mdpi.com/1999-4923/11/6/263

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