6533b86ffe1ef96bd12ce82a
RESEARCH PRODUCT
P-chirogenic organocatalysts: application to the aza-Morita–Baylis–Hillman (aza-MBH) reaction of ketimines
Vellaisamy SridharanHiroaki SasaiJérôme BayardonShinobu TakizawaYasushi YoshidaSylvain JugéEmmanuelle RémondFernando Arteaga Arteagasubject
chemistry.chemical_classificationMetals and AlloysEnantioselective synthesisStereoisomerismStereoisomerismGeneral ChemistryCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsCatalysisAmino acidchemistryNitrilesMaterials ChemistryCeramics and CompositesOrganic chemistryIminesAmino Acidsdescription
The P-chirogenic organocatalysts were found to promote the enantioselective aza-Morita-Baylis-Hillman reaction of ketimines derived from acyclic α-keto esters. In the P-chirogenic organocatalyzed aza-MBH reactions, α,α-disubstituted α-amino acid derivatives were obtained in high yields with high enantioselectivities (up to 97% ee).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-08-14 | Chemical Communications |