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RESEARCH PRODUCT

Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?

Guido SireciRoberto GiacomelliDiana Di LibertoAngelo FerranteFrancesco CicciaGiovanni TrioloBalistrericarmela RitaGiuliana GugginoPaola Cipriani

subject

Vasculitis0301 basic medicineVasculitiAgingEndotheliumAutoimmune Diseases03 medical and health sciences0302 clinical medicineMedicineAnimalsHumansRheumatoid arthritisProgenitor cellRheumatoid arthritiEndothelial Progenitor Cells030203 arthritis & rheumatologyColony-forming unitScleroderma SystemicbiologyEPCs; LES; Rheumatoid arthritis; Vasculitis; Aging; Developmental Biologybusiness.industryEPCmedicine.diseaseFibronectinSettore MED/16 - Reumatologia030104 developmental biologymedicine.anatomical_structureLESEPCsImmunologyembryonic structuresbiology.proteincardiovascular systemBone marrowEndothelium VascularbusinessVasculitisFunction (biology)circulatory and respiratory physiologyDevelopmental Biology

description

Endothelial Progenitor Cells (EPCs) are bone marrow derived cells able to differentiate in mature endothelial cells (EC) contributing to the generation of new vessels, connecting to fibronectin, and forming colonies and/or colony forming units. Since circulating EPCs can be actively considered part of endothelial damage in several cardiovascular diseases and autoimmune disorders the possibility to have a measure for endothelium damage should be considered of interest to predict the patient out-come. At the same time the EPCs proliferative and regenerative role could be considered for therapeutic applications. Studies have been performed to elucidate the role of EPCs in Systemic Sclerosis and many review and articles published on this topic. In the present paper we aimed to review the role of EPCs in other autoimmune disorders.

yearjournalcountryeditionlanguage
2016-01-01Mechanisms of ageing and development
10.1016/j.mad.2016.05.001https://pubmed.ncbi.nlm.nih.gov/27153975