6533b86ffe1ef96bd12ce8b4

RESEARCH PRODUCT

Quantitative characterization of antigens using monoclonal antibody reactivities

Joaquín DopazoAna TabernerAndrés Moya

subject

Statistics and ProbabilityAnticorps monoclonalmedicine.drug_classComputational biologyMonoclonal antibodyBiochemistryEpitopeEpitopesAntigenMicrocomputersAntibodies monoclonalmedicineAntigensMolecular BiologyMathematicsbiologyAntibodies MonoclonalVirologyComputer Science ApplicationsQuantitative measureComputational MathematicsComputational Theory and Mathematicsbiology.proteinAntibodyAlgorithmsSoftware

description

A multipurpose program that empirically relates antigenic reactivities with monoclonal antibodies (MAbs) to genetic distances is presented. The program uses a set of known genetic pairwise distances to weigh each MAb depending on its capacity to define groups of taxonomically related antigens. This allows highly accurate identification and classification of unknown antigens. Also, the weights obtained constitute a quantitative measure of epitope conservation and can be used for improved vaccine design. © 1993 Oxford University Press.

yearjournalcountryeditionlanguage
1993-02-01
10.1093/bioinformatics/9.1.101http://hdl.handle.net/10261/290008