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RESEARCH PRODUCT

Agouti-related peptide-expressing neurons are mandatory for feeding.

Brigitte HampelEva GroppTamas L. HorvathLeona PlumAri WaismanAllison W. XuMarya ShanabroughJens C. BrüningNina BalthasarErzsebet BorokGregory S. BarshThorsten BuchRuth Janoschek

subject

medicine.medical_specialtyPro-OpiomelanocortinTime FactorsPeptideCell CountBiologyEnergy homeostasisEatingMiceArcuate nucleusInternal medicinemedicineAnimalsAgouti-Related ProteinDiphtheria ToxinNeuropeptide YRegulation of gene expressionchemistry.chemical_classificationMice KnockoutNeuronsGeneral Neurosciencedigestive oral and skin physiologyBody WeightArcuate Nucleus of HypothalamusProteinsFeeding BehaviorNeuropeptide Y receptorbeta-GalactosidaseAnorexiaEndocrinologynervous systemchemistryGene Expression RegulationHypothalamusIntercellular Signaling Peptides and ProteinsAgouti-related peptidehormones hormone substitutes and hormone antagonistsHormone

description

Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis.

yearjournalcountryeditionlanguage
2005-09-11Nature neuroscience
10.1038/nn1548https://pubmed.ncbi.nlm.nih.gov/16158063