6533b86ffe1ef96bd12ce917
RESEARCH PRODUCT
Changes of neurohumoral parameters and endothelin-1 in response to exercise in patients with mild to moderate congestive heart failure
Rainer J. ZotzSabine Genth-zotzJ. MeyerM CobaughHarald DariusVan Dirk VeldhuisenT Netzersubject
Malemedicine.medical_specialtyHeart diseaseneurohumoral activationheart failurePeptide hormonePLASMA ENDOTHELINInternal medicinemedicineHumanscardiovascular diseasesExercise physiologyExerciseAgedNeurotransmitter AgentsEndothelin-1BLOOD-FLOWbusiness.industryBlood flowMiddle Agedmedicine.diseaseEndothelin 1Pathophysiologyexercise capacityEndocrinologyHeart failureExercise TestCardiologycardiovascular systemFemaleCardiology and Cardiovascular MedicineEndothelin receptorbusinessendothelindescription
Plasma endothelin levels are increased in patients with moderate and severe CHF. Conflicting data exist about the endothelin-1 (ET) level in patients with mild to moderate CHF and the effect of maximal exercise on plasma ET levels.We determined the plasma levels of ET and various neurohumoral parameters in 93 patients with CHF in functional class II and III of the NYHA classification at rest and after maximal bicycle exercise. Baseline ET level was increased compared to an age-matched healthy volunteer group (6.95+/-0.31 vs 3.29+/-0.17 pg/ml, mean+/-S.E.M., P0.05), without significant differences between NYHA class II and III patients. Maximal exercise did not increase the ET level. In contrast, the neurohumoral parameters were significantly increased with maximal exercise. In conclusion, plasma levels of ET are increased in patients with mild to moderate CHF. However, no further increase in response to exercise was observed. Thus, it is highly unlikely that exercise capacity may be limited by ET-mediated peripheral vasoconstriction.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-11-26 |