6533b86ffe1ef96bd12ce955

RESEARCH PRODUCT

Adenosine activates a potassium conductance in guinea-pig atrial heart muscle.

H. NawrathG. Jochem

subject

medicine.medical_specialtyContraction (grammar)AdenosineVoltage clampPotassiumGuinea Pigschemistry.chemical_elementAction PotentialsGuinea pigCellular and Molecular NeuroscienceInternal medicinemedicineAnimalsHeart AtriaMolecular BiologyPharmacologyAtrium (architecture)Electric ConductivityHeartCell BiologyAdenosineMyocardial ContractionElectrophysiologyEndocrinologychemistryCirculatory systemPotassiumMolecular Medicinemedicine.drug

description

Adenosine shortens the action potential and diminishes the force of contraction in guinea-pig left atria. These effects may be brought about by the activation of a potassium conductance. This assumption is supported by voltage clamp and 42K release experiments.

10.1007/bf01990096https://pubmed.ncbi.nlm.nih.gov/6653721