6533b870fe1ef96bd12cf112

RESEARCH PRODUCT

Enhanced Efficacy and Broadening of Antibacterial Action of Drugs via the Use of Capped Mesoporous Nanoparticles

Pedro AmorósNúria MasLaura MondragónMaría D. MarcosNuria CabedoFélix SancenónIrene GalianaJosé Ramón MurguíaRamón Martínez-máñezEstela ClimentElena Aznar

subject

INGENIERIA DE LA CONSTRUCCIONNanoparticleNanotechnologyMicrobial Sensitivity TestsCatalysisQUIMICA ORGANICAVancomycinGram-Negative BacteriaQUIMICA ANALITICABIOQUIMICA Y BIOLOGIA MOLECULARmedicinePolylysineGated materialsNanodeviceDrug CarriersChemistryQUIMICA INORGANICAOrganic ChemistryGeneral ChemistrySilicon DioxideAntimicrobialMesoporous materialsAnti-Bacterial AgentsAntimicrobial drugepsilon-poly-L-lysineNanoparticlesVancomycinAntibacterial actionMesoporous materialPorositymedicine.drug

description

[EN] A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with epsilon-poly-L-lysine (epsilon-PL) was prepared and its interaction with different Gram-negative bacteria studied. A remarkable improvement in the efficacy of the antimicrobial drug epsilon-PL and a broadening of the antimicrobial spectrum of vancomycin is demonstrated.

yearjournalcountryeditionlanguage
2013-07-09Chemistry - A European Journal
https://doi.org/10.1002/chem.201302170